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M94A2422.TXT
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1994-10-25
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Document 2422
DOCN M94A2422
TI Perinatal transmission among women seroconverting during pregnancy,
Bangkok.
DT 9412
AU Shaffer N; Roongpisuthipong A; Siriwasin W; Wasi C; Kaewchaiyo G;
Chearskul S; Chotpitayasunondh T; HIV/AIDS Collaboration, Bangkok,
Thailand.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):308 (abstract no. PC0163). Unique
Identifier : AIDSLINE ICA10/94370153
AB OBJECTIVES: Newly infected women may be at highest risk of vertical
transmission due to transient high circulating viral load. This study
aims to determine the immunologic and virologic characteristics and risk
of vertical transmission for pregnant women who seroconvert during
pregnancy. METHODS: At 2 large hospitals with routine HIV counseling and
testing at first and late 3rd trimester antenatal visits, pregnant women
documented to have seroconverted during pregnancy are enrolled as a
special subgroup in a prospective mother-child perinatal transmission
study. Seroconverting pregnant women (SC) were compared with those
testing HIV positive at enrollment (POS). RESULTS: The background
antenatal HIV seroprevalence in 1993 was 2%. From Nov 1992 through Jan
1994, 313 HIV infected women have been enrolled during pregnancy,
including 11 SC. Available immunologic data (% and median values) are:
TABULAR DATA, SEE ABSTRACT VOLUME. The background vertical transmission
rate in the cohort is 26%. Thus far, 1/6 (17%) of SC has transmitted
infection to her infant. Enrollment and laboratory studies are
continuing. CONCLUSIONS: On initial testing, women identified to
seroconvert during pregnancy appear to have similar or lower immune
markers than seropositive pregnant women entering antenatal care.
Further characterization of the immune profile, viral load, and risk of
vertical transmission in this group may lead to a better understanding
of the mechanisms of vertical transmission.
DE CD4-CD8 Ratio Female Human HIV
Infections/IMMUNOLOGY/MICROBIOLOGY/*TRANSMISSION *HIV Seropositivity
Infant, Newborn Pregnancy *Pregnancy Complications,
Infectious/IMMUNOLOGY/MICROBIOLOGY Risk Factors T-Lymphocyte Subsets
MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).